Article

Loss of Brg1 promotes seizure development via GABAergic system disruption

2026-02-26

Abstract excerpt

The Brahma-related gene 1 ( BRG1 ) encodes the catalytic subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex and plays an important role in brain development. Variants in SWI/SNF components are often found in patients with epilepsy, but it is still unclear how loss of BRG1 function contributes to seizure development. In this study, we analyzed the role of Brg1 in seizure susceptib...

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Literature Corpus work: 346b0487-9de8-50e6-bc79-824be24c07e1
DOI: 10.64898/2026.02.25.706532

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