SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.

doi:10.1534/genetics.104.029439

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Article

SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.

Genetics - 1 Sept 2004

Zraly Claudia B, Marenda Daniel R, Dingwall Andrew K

Abstract excerpt

SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1). Increased cell growth and wing patterning defects are associated with a conditional snr1 mutant, while loss of INI1 function is directly linked with aggressive cancers, suggesting important roles in development and growth control. The Brm complex is known to...

Topics

Animals
CDC2-CDC28 Kinases
Cell Cycle
Cell Cycle Proteins
Cell Growth Processes
Chromatin Assembly and Disassembly
Cyclin-Dependent Kinase 2
Drosophila Proteins
Drosophila melanogaster
Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluorescent Antibody Technique

G1 Phase

Gene Expression Regulation, Developmental

Glutathione Transferase

Mutation

Phenotype

Protein Tyrosine Phosphatases

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 15454538
DOI: 10.1534/genetics.104.029439
PMCID: PMC1448117

Genes

CDK2

Provenance

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SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.PMID 15454538Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.Semantic proximity Read ↗

The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions.Semantic proximity Read ↗

Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function.Semantic proximity Read ↗

The BRG1 ATPase of Human SWI/SNF Chromatin Remodeling Enzymes as a Driver of CancerSemantic proximity Read ↗

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Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene ExpressionSemantic proximity Read ↗

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Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.Semantic proximity Read ↗

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsSemantic proximity Read ↗

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