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Article

SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.

Genetics - 1 Sept 2004

Zraly Claudia B, Marenda Daniel R, Dingwall Andrew K

Abstract excerpt

SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1). Increased cell growth and wing patterning defects are associated with a conditional snr1 mutant, while loss of INI1 function is directly linked with aggressive cancers, suggesting important roles in development and growth control. The Brm complex is known to...

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Identifiers

PMID: 15454538
DOI: 10.1534/genetics.104.029439
PMCID: PMC1448117

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.PMID 15454538Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.Semantic proximity Read ↗

The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions.Semantic proximity Read ↗

Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function.Semantic proximity Read ↗

The BRG1 ATPase of Human SWI/SNF Chromatin Remodeling Enzymes as a Driver of CancerSemantic proximity Read ↗

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Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene ExpressionSemantic proximity Read ↗

Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated.Semantic proximity Read ↗

Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.Semantic proximity Read ↗

Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer.Semantic proximity Read ↗

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsSemantic proximity Read ↗

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