Article
Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.
The Journal of biological chemistry - 10 Nov 2017
Padilla-Benavides Teresita, Nasipak Brian T, Paskavitz Amanda L, Haokip Dominic T, Schnabl Jake M, Nickerson Jeffrey A, Imbalzano Anthony N
Abstract excerpt
Transcriptional regulation is modulated in part by chromatin-remodeling enzymes that control gene accessibility by altering chromatin compaction or nucleosome positioning. Brahma-related gene 1 (Brg1), a catalytic subunit of the mammalian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast proliferation and differentiation, and the control of Brg1 phosphorylation by calcineurin, PKCβ1, and p38...
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