Article
Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring.
Cell reports - 13 Jul 2021
Hong Weiling, Zhang Jian, Dong Haiyang, Shi Yang, Ma Hongru, Zhou Fengyan, Xu Bingbing, Fu Ying, Zhang Shixin, Hou Shouqing, Li Guo, Wu Yandan, Chen Shuo, Zhu Xiaohua, You Wendong, Shi Feng, Yang Xiaofeng, Gong Zhefeng, Huang Jianhua, Jin Yongfeng
Abstract excerpt
Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can generate 38,016 different isoforms through largely stochastic, yet highly biased, alternative splicing. These isoforms are required for nervous functions. However, the functional significance of splicing bias remains unknown. Here, we provide evidence that Dscam1 splicing bias is required for mushroom body (MB) axonal wiring. We generate...
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