Article

Intron-targeted mutagenesis reveals roles for <i>Dscam1</i> RNA pairing-mediated splicing bias in neuronal wiring

2019-04-29

Abstract excerpt

Drosophila melanogaster Down syndrome cell adhesion molecule ( Dscam1 ) can potentially generate 38,016 different isoforms through stochastic, yet highly biased, alternative splicing. Genetic studies demonstrated that stochastic expression of multiple Dscam1 isoforms provides each neuron with a unique identity for self/non-self-discrimination. However, due to technical obstacles, the functional significance of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa9ba733-2355-5ec1-8d44-4b44f0c32a9b
DOI: 10.1101/622217

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intron-targeted mutagenesis reveals roles for <i>Dscam1</i> RNA pairing-mediated splicing bias in neuronal wiringDOI 10.1101/622217Read

Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring.Semantic proximity Read

Stochastic splicing and deterministic inclusion of variable exons promote diversification of <i>Down Syndrome Cell Adhesion Molecule</i> expressionSemantic proximity Read

Dscam diversity is essential for neuronal wiring and self-recognition.Semantic proximity Read

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.Semantic proximity Read

Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation.Semantic proximity Read

The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.Semantic proximity Read

Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies.Semantic proximity Read

Stochastic yet biased expression of multiple Dscam splice variants by individual cells.Semantic proximity Read

PXGS: a Poly-Transgene Expression System based on Mutually Exclusive Splicing of DscamSemantic proximity Read

Generation of recognition diversity in the nervous system.Semantic proximity Read

Srrm234, but not canonical SR and hnRNP proteins drive inclusion of <i>Dscam</i> exon 9 variable exonsSemantic proximity Read

Homophilic Dscam interactions control complex dendrite morphogenesis.Semantic proximity Read