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Article

The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.

Cell - 5 May 2006

Chen Brian E, Kondo Masahiro, Garnier Amélie, Watson Fiona L, Püettmann-Holgado Roland, Lamar David R, Schmucker Dietmar

Abstract excerpt

Alternative splicing of Dscam generates an enormous molecular diversity with maximally 38,016 different receptors. Whether this large diversity is required in vivo is currently unclear. We examined the role of Dscam in neuron-target recognition of single mechanosensory neurons, which connect with different target cells through multiple axonal branches. Analysis of Dscam null neurons demonstrated an essential role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16678102
DOI: 10.1016/j.cell.2006.03.034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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