Article
Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution.
RNA (New York, N.Y.) - 1 Jan 2010
Lee Christopher, Kim Namshin, Roy Meenakshi, Graveley Brenton R
Abstract excerpt
The arthropod Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of protein isoforms via combinatorial splicing of numerous alternative exons encoding immunoglobulin variable domains organized into three clusters referred to as the exon 4, 6, and 9 clusters. Dscam pr...
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