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Article

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.

Nature - 1 Oct 2009

Hattori Daisuke, Chen Yi, Matthews Benjamin J, Salwinski Lukasz, Sabatti Chiara, Grueber Wesley B, Zipursky S Lawrence

Abstract excerpt

Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily. In Drosophila, Dscam1 generates 19,008 different ectodomains by alternative splicing of three exon clusters, each encoding half or a complete variable immunoglobulin domain. Identical isoforms bind to each other, but rarely to isoforms differing at any one of the variable immunoglobulin...

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Identifiers

PMID: 19794492
DOI: 10.1038/nature08431
PMCID: PMC2836808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.PMID 19794492Read ↗

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