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Article

Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation.

Science (New York, N.Y.) - 6 Jun 2014

He Haihuai, Kise Yoshiaki, Izadifar Azadeh, Urwyler Olivier, Ayaz Derya, Parthasarthy Akhila, Yan Bing, Erfurth Maria-Luise, Dascenco Dan, Schmucker Dietmar

Abstract excerpt

The isoform diversity of the Drosophila Dscam1 receptor is important for neuronal self-recognition and self-avoidance. A canonical model suggests that homophilic binding of identical Dscam1 receptor isoforms on sister dendrites ensures self-avoidance even when only a single isoform is expressed. We detected a cell-intrinsic function of Dscam1 that requires the coexpression of multiple isoforms. Manipulation of...

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Identifiers

PMID: 24831526
DOI: 10.1126/science.1251852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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