Article
The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 12 Aug 2022
Klinpudtan Nonglak, Allsopp Richard C, Kabayama Mai, Godai Kayo, Gondo Yasuyuki, Masui Yukie, Akagi Yuya, Srithumsuk Werayuth, Sugimoto Ken, Akasaka Hiroshi, Takami Yoichi, Takeya Yasushi, Yamamoto Koichi, Ikebe Kazunori, Yasumoto Saori, Ogawa Madoka, Ishizaki Tatsuro, Arai Yasumichi, Rakugi Hiromi, Chen Randi, Willcox Bradley J, Willcox D Craig, Kamide Kei
Abstract excerpt
The G allele of FOXO3 gene (single-nucleotide polymorphism; rs2802292) is strongly associated with human longevity. However, knowledge of the effect of FOXO3 in older populations, men or women, with heart disease is limited. This cross-sectional study in Japan included 1836 older adults in the 70- and 80-year-old groups. DNA samples isolated from buffy coat samples of peripheral blood were used to genotype FOXO3...
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