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Article

Association of FOXO3A variation with human longevity confirmed in German centenarians.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2009

Flachsbart Friederike, Caliebe Amke, Kleindorp Rabea, Blanché Hélène, von Eller-Eberstein Huberta, Nikolaus Susanna, Schreiber Stefan, Nebel Almut

Abstract excerpt

The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms. A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a discovery sample of long-lived men of Japanese ancestry [Willcox et al. (2008) Proc Natl Acad...

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Identifiers

PMID: 19196970
DOI: 10.1073/pnas.0809594106
PMCID: PMC2650329

Genes

IGF1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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