FOXO3 Longevity Genotype Mitigates Risk Posed by Hypertension on Incident Coronary Artery Disease in Middle-Aged Men: Kuakini Honolulu Heart Program.

doi:10.1093/gerona/glae254

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FOXO3 Longevity Genotype Mitigates Risk Posed by Hypertension on Incident Coronary Artery Disease in Middle-Aged Men: Kuakini Honolulu Heart Program.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2024

Chen Randi, Morris Brian J, Donlon Timothy A, Nakagawa Kazuma, Allsopp Richard C, Willcox Bradley J, Masaki Kamal H

Abstract excerpt

BACKGROUND: This study tested whether the carriage of the longevity-associated G-allele of FOXO3 SNP rs2802292 (TG/GG) protects against incident coronary artery disease (CAD) in men with hypertension. METHODS: Subjects were American men residing on Oahu having Japanese (n = 5415) or Okinawan (n = 897) ancestry and free of CAD at baseline (1965-1968) when aged 45-68 years. RESULTS: During the follow-up, there were...

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PMID: 39497655
DOI: 10.1093/gerona/glae254
PMCID: PMC11642614

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CAD
TG
FOXO3

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