Article
The FoxO3 gene and cause-specific mortality.
Aging cell - 1 Aug 2016
Willcox Bradley J, Tranah Gregory J, Chen Randi, Morris Brian J, Masaki Kamal H, He Qimei, Willcox D Craig, Allsopp Richard C, Moisyadi Stefan, Poon Leonard W, Rodriguez Beatriz, Newman Anne B, Harris Tamara B, Cummings Steven R, Liu Yongmei, Parimi Neeta, Evans Daniel S, Davy Phil, Gerschenson Mariana, Donlon Timothy A
Abstract excerpt
The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide. The aims of this study were to quantify the mortality risk for the longevity-associated genotype and to discover the particular cause(s) of death associated with this allele in older Americans of diverse ancestry. It involved a 17-year...
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