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Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases

23 Dec 2021

Abstract excerpt

Forkhead box O3 (FOXO3) has been proposed as a homeostasis regulator, capable of integrating multiple upstream signaling pathways that are sensitive to environmental changes and counteracting their adverse effects due to external changes, such as oxidative stress, metabolic stress and growth factor deprivation. FOXO3 polymorphisms are associated with extreme human longevity. Intriguingly, longevity-associated...

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PMID: 35004893
DOI: 10.3389/fcvm.2021.778674

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