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Article

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

Human molecular genetics - 15 Dec 2009

Li Yang, Wang Wen-Jing, Cao Huiqing, Lu Jiehua, Wu Chong, Hu Fang-Yuan, Guo Jian, Zhao Ling, Yang Fan, Zhang Yi-Xin, Li Wei, Zheng Gu-Yan, Cui Hanbin, Chen Xiaomin, Zhu Zhiming, He Hongbo, Dong Birong, Mo Xianming, Zeng Yi, Tian Xiao-Li

Abstract excerpt

FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently been linked to human longevity in Japanese, German and Italian populations. Here we tested the genetic contribution of FOXO1A and FOXO3A to the longevity phenotype in Han Chinese population. Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals. Two SNPs of FOXO1A were found to be...

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PMID: 19793722
DOI: 10.1093/hmg/ddp459
PMCID: PMC2790334

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