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Article

Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation.

Nucleic acids research - 5 May 2017

Mendizabal Isabel, Zeng Jia, Keller Thomas E, Yi Soojin V

Abstract excerpt

Genomic DNA methylation maps (methylomes) encode genetic and environmental effects as stable chemical modifications of DNA. Variations in DNA methylation, especially in regulatory regions such as promoters and enhancers, are known to affect numerous downstream processes. In contrast, most transcription units (gene bodies) in the human genome are thought to be heavily methylated. However, epigenetic reprogramming...

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PMID: 28115635
DOI: 10.1093/nar/gkx020
PMCID: PMC5416765

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