Article
Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.
Human molecular genetics - 1 Jun 2013
Hindle Samantha, Afsari Farinaz, Stark Meg, Middleton C Adam, Evans Gareth J O, Sweeney Sean T, Elliott Christopher J H
Abstract excerpt
Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision. As both mammalian and fly visual systems contain dopaminergic neurons, we investigated the effect of LRRK2 mutations (the most common cause of inherited PD) on Drosophila electroretinograms (ERGs). We reveal progressive loss of photoreceptor function in flies expressing LRRK2-G2019S in...
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