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Article

LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.

Human molecular genetics - 1 Apr 2017

Marcogliese Paul C, Abuaish Sameera, Kabbach Ghassan, Abdel-Messih Elizabeth, Seang Sarah, Li Gang, Slack Ruth S, Haque M Emdadul, Venderova Katerina, Park David S

Abstract excerpt

Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the primary cause for motor symptoms observed in Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most commonly linked contributor to familial PD. LRRK2 is suggested to be involved in a wide variety of cellular processes, but deciphering its role in the pathogenesis of PD has been...

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Identifiers

PMID: 28158614
DOI: 10.1093/hmg/ddx030
PMCID: PMC6075539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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