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Adolescent nicotine induces depressive and anxiogenic effects through ERK 1-2 and Akt-GSK-3 pathways and neuronal dysregulation in the nucleus accumbens.

Addiction biology - 1 Mar 2021

Hudson Roger, Green Matthew, Wright Daniel J, Renard Justine, Jobson Christina E L, Jung Tony, Rushlow Walter, Laviolette Steven R

Abstract excerpt

Long-term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that manifest as a variety of neuropsychiatric comorbidities in clinical and preclinical studies, including mood and anxiety-related disorders. The nucleus accumbens shell (NASh) is critically involved in regulating emotional processing, and both molecular and...

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PMID: 32135573
DOI: 10.1111/adb.12891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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