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Article

Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.

Biological psychiatry - 15 Nov 2013

Parise Eric M, Alcantara Lyonna F, Warren Brandon L, Wright Katherine N, Hadad Roey, Sial Omar K, Kroeck Kyle G, Iñiguez Sergio D, Bolaños-Guzmán Carlos A

Abstract excerpt

BACKGROUND: Major depressive disorder afflicts up to 10% of adolescents. However, nearly 50% of those afflicted are considered nonresponsive to available treatments. Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist has shown potential as a rapid-acting and long-lasting treatment for major depressive disorder in adults. Thus, the effectiveness and functional consequences of ketamine exposure...

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Identifiers

PMID: 23790225
DOI: 10.1016/j.biopsych.2013.04.027
PMCID: PMC3785550

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