Article
Adolescent Nicotine Exposure Induces Dysregulation of Mesocorticolimbic Activity States and Depressive and Anxiety-like Prefrontal Cortical Molecular Phenotypes Persisting into Adulthood.
Cerebral cortex (New York, N.Y. : 1991) - 5 Jul 2019
Jobson Christina L M, Renard Justine, Szkudlarek Hanna, Rosen Laura G, Pereira Brian, Wright Daniel J, Rushlow Walter, Laviolette Steven R
Abstract excerpt
Considerable evidence demonstrates strong comorbidity between nicotine dependence and mood and anxiety disorders. Nevertheless, the neurobiological mechanisms linking adolescent nicotine exposure to mood and anxiety disorders are not known. Disturbances in the mesocorticolimbic dopamine (DA) system, comprising the prefrontal cortex (PFC), ventral tegmental area (VTA), and nucleus accumbens (NAc), are correlates...
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