Article

Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats

2026-07-01

Abstract excerpt

Treatment-resistant depression and anxiety remain major challenges in psychiatry, particularly in female patients, who are disproportionately affected yet remain underrepresented in preclinical ketamine research. The present study investigated short- and long-term anxiolytic effects of acute subanesthetic ketamine administration in female Wistar-Kyoto (WKY) rats, a validated genetic model of treatment-resistant af...

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Literature Corpus work: fd7e453f-7eb5-5eb7-89cb-f4baeeab8e1e
DOI: 10.64898/2026.06.26.734907

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