Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system.

doi:10.1038/s41386-024-01853-y

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Article

Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2024

Ng Tsun Hay Jason, Sarikahya Mohammed H, Hudson Roger, Szkudlarek Hanna J, Pérez-Valenzuela Enzo, Uzuneser Taygun C, Proud Emma, Gummerson Dana, Youssef Miray, Machado Madeline, Zhaksylyk Kuralay, DeVuono Marieka V, Chen Chaochao, Yeung Ken K-C, Rushlow Walter J, Laviolette Steven R

Abstract excerpt

The majority of lifetime smokers begin using nicotine during adolescence, a critical period of brain development wherein neural circuits critical for mood, affect and cognition are vulnerable to drug-related insults. Specifically, brain regions such as the medial prefrontal cortex (mPFC), the ventral tegmental area (VTA), nucleus accumbens (NAc) and hippocampus, are implicated in both nicotine dependence and...

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PMID: 38521861
DOI: 10.1038/s41386-024-01853-y
PMCID: PMC11109238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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