Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.

doi:10.1186/s12936-018-2205-9

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Article

Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.

Malaria journal - 5 Feb 2018

Diop Gora, Derbois Céline, Loucoubar Cheikh, Mbengue Babacar, Ndao Bineta Niakhana, Thiam Fatou, Thiam Alassane, Ndiaye Rokhaya, Dieye Yakhya, Olaso Robert, Deleuze Jean-Francois, Dieye Alioune

Abstract excerpt

BACKGROUND: Severe forms of malaria (SM) are an outcome of Plasmodium falciparum infection and can cause death especially in children under 4 years of age. RNASE3 (ECP) has been identified as an inhibitor of Plasmodium parasites growth in vitro, and genetic analysis in hospitalized Ghanaian subjects has revealed the RNASE3 +371G/C (rs2073342) polymorphism as a susceptibility factor for cerebral malaria. The +371...

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Identifiers

PMID: 29402293
DOI: 10.1186/s12936-018-2205-9
PMCID: PMC5800030

Genes

RNASE3
MAF

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