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Article

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.

Cancer research - 1 Jan 2016

Emir Uzay E, Larkin Sarah J, de Pennington Nick, Voets Natalie, Plaha Puneet, Stacey Richard, Al-Qahtani Khalid, Mccullagh James, Schofield Christopher J, Clare Stuart, Jezzard Peter, Cadoux-Hudson Tom, Ansorge Olaf

Abstract excerpt

Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas, where they are associated with abnormal accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Monitoring 2-HG levels could provide prognostic information in this disease, but detection strategies that are noninvasive and sufficiently quantitative have yet to be developed. In this study, we address this need by...

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Identifiers

PMID: 26669865
DOI: 10.1158/0008-5472.CAN-15-0934
PMCID: PMC4704134

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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