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Article

Quantitative analysis of 2-hydroxyglutarate as a controversial oncometabolite in malignant gliomas.

Neoplasma - 1 Nov 2020

Bystricky P, Kasubova I, Richterova R, Lasabova Z, Kolarovszki B

Abstract excerpt

There is a great effort to connect the accumulation of 2-hydroxyglutarate (2-HG) oncometabolite with cellular onco-epigenetic status and subsequently predict the prognoses of glioma patients. In this observational study, the concentrations of D- and L- 2-HG were determined in 57 tumor tissue samples of glioma patients (n=57) WHO grade I through IV (astrocytoma, oligodendroglioma, secondary glioblastoma, and...

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PMID: 32853017
DOI: 10.4149/neo_2020_200302N216

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