The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity.

doi:10.3390/ijms22116100

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Article

The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity.

International journal of molecular sciences - 5 Jun 2021

Ferri Flaminia, Carotti Simone, Carpino Guido, Mischitelli Monica, Cantafora Alfredo, Molinaro Antonio, Argenziano Maria Eva, Parisse Simona, Corsi Alessandro, Riminucci Mara, Lai Quirino, Mennini Gianluca, Spadetta Gustavo, Pugliese Francesco, Rossi Massimo, Morini Sergio, Gaudio Eugenio, Ginanni Corradini Stefano

Abstract excerpt

In nonalcoholic steatohepatitis animal models, an increased lipid droplet size in hepatocytes is associated with fibrogenesis. Hepatocytes with large droplet (Ld-MaS) or small droplet (Sd-MaS) macrovesicular steatosis may coexist in the human liver, but the factors associated with the predominance of one type over the other, including hepatic fibrogenic capacity, are unknown. In pre-ischemic liver biopsies from...

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PMID: 34198853
DOI: 10.3390/ijms22116100
PMCID: PMC8200978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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