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A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease.

International journal of molecular sciences - 2 Jul 2024

Doueiry Caren, Kappler Christiana S, Martinez-Morant Carla, Duncan Stephen A

Abstract excerpt

The incidence of nonalcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated fatty liver disease (MAFLD), is increasing in adults and children. Unfortunately, effective pharmacological treatments remain unavailable. Single nucleotide polymorphisms (SNPs) in the patatin-like phospholipase domain-containing protein (PNPLA3 I148M) have the most significant genetic association with the disease at...

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Acyltransferases
Hepatocytes
Induced Pluripotent Stem Cells
Lipase
Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Non-alcoholic Fatty Liver Disease

Phospholipases A2, Calcium-Independent

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Identifiers

PMID: 39000384
DOI: 10.3390/ijms25137277
PMCID: PMC11242544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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