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Article

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

1 Sept 2022

Abstract excerpt

Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of broadly immunodeficient chimeric mice...

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PMID: 36103835
DOI: 10.1016/j.celrep.2022.111321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric micePMID 36103835Read ↗

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