Article
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
DNA repair - 1 Sept 2021
Paluri Sesha L, Burak Matthew, Senejani Alireza G, Levinson Madison, Rahim Tania, Clairmont Kaylyn, Kashgarian Michael, Alvarado-Cruz Isabel, Meas Rithy, Cardó-Vila Marina, Zeiss Caroline, Maher Stephen, Bothwell Alfred L M, Coskun Erdem, Kant Melis, Jaruga Pawel, Dizdaroglu Miral, Stephen Lloyd R, Sweasy Joann B
Abstract excerpt
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in microhomology-mediated end-joining. We have previously shown that the PolbY265C/+ and PolbY265C/C mice develop lupus. These mice exhibit high levels of antinuclear...
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