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Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice

18 Jul 2022

Abstract excerpt

DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary conserved DNA exonuclease involved in various DNA repair pathways, replication, antibody diversification, and meiosis. But, whether EXO1 facilitates these DNA metabolic processes through its enzymatic or scaffolding functions remains unclear. Here, we dissect the...

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Cancer Genomics and Diagnostics
DNA Repair Mechanisms
Genetic factors in colorectal cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35849338
DOI: 10.1093/nar/gkac616

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Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A micePMID 35849338Read ↗

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