Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Zha Shan, Alt Frederick W, Cheng Hwei-Ling, Brush James W, Li Gang

Abstract excerpt

Nonhomologous DNA end-joining (NHEJ) is a major pathway of DNA double-strand break (DSB) repair in mammalian cells, and it functions to join both specifically programmed DSBs that occur in the context of V(D)J recombination during early lymphocyte development as well as general DSBs that occur in all cells. Thus, defects in NHEJ impair V(D)J recombination and lead to general genomic instability. In human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Genomic Instability

Share to In Situ Hybridization, Fluorescence

Share to Lymphocytes

Share to Recombination, Genetic

Share to VDJ Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 17360556
DOI: 10.1073/pnas.0611734104
PMCID: PMC1838633

Genes

NHEJ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.PMID 17360556Read ↗

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.Semantic proximity Read ↗

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Semantic proximity Read ↗

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.Semantic proximity Read ↗

Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1Semantic proximity Read ↗

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesisSemantic proximity Read ↗

Interplay between Cernunnos-XLF and Nonhomologous End-joining Proteins at DNA Ends in the CellSemantic proximity Read ↗

Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations.Semantic proximity Read ↗

Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and HumansSemantic proximity Read ↗

Novel XLF/Cernunnos mutation linked to severe combined immunodeficiency, microcephaly and abnormal T and B cell receptor repertoiresSemantic proximity Read ↗

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repairSemantic proximity Read ↗

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.