Article
Polμ deficiency increases resistance to oxidative damage and delays liver aging.
PloS one - 1 Jan 2014
Escudero Beatriz, Lucas Daniel, Albo Carmen, Dhup Suveera, Bacher Jeff W, Sánchez-Muñoz Aránzazu, Fernández Margarita, Rivera-Torres José, Carmona Rosa M, Fuster Encarnación, Carreiro Candelas, Bernad Raquel, González Manuel A, Andrés Vicente, Blanco Luis, Roche Enrique, Fabregat Isabel, Samper Enrique, Bernad Antonio
Abstract excerpt
Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ(-/-)) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ(-/-) mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ(-/-) deficiency on...
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