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Article

DNA polymerase beta is critical for genomic stability of sperm cells.

DNA repair - 3 Apr 2011

Kidane Dawit, Dalal Shibani, Keh Agnes, Liu Yanfeng, Zelterman Daniel, Sweasy Joann B

Abstract excerpt

Maintaining genome integrity in germ cells is important, given that the germ cells produce the next generation of offspring. Base excision repair is a DNA repair pathway that is responsible for the repair of most endogenous DNA damage. A key enzyme that functions in this repair pathway is DNA polymerase beta (Pol β). We previously used conditional gene targeting to engineer mice with sperm deleted of the Pol B...

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Identifiers

PMID: 21333614
DOI: 10.1016/j.dnarep.2011.01.003
PMCID: PMC3255305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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