Article
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis.
Molecular and cellular biology - 1 Nov 2007
Venkatesan Ranga N, Treuting Piper M, Fuller Evan D, Goldsby Robert E, Norwood Thomas H, Gooley Ted A, Ladiges Warren C, Preston Bradley D, Loeb Lawrence A
Abstract excerpt
Mammalian DNA polymerase delta (Pol delta) is believed to replicate a large portion of the genome and to synthesize DNA in DNA repair and genetic recombination pathways. The effects of mutation in the polymerase domain of this essential enzyme are unknown. Here, we generated mice harboring an L604G or L604K substitution in highly conserved motif A in the polymerase active site of Pol delta. Homozygous...
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