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Article

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Grieves Jessica L, Fye Jason M, Harvey Scott, Grayson Jason M, Hollis Thomas, Perrino Fred W

Abstract excerpt

The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to double-stranded DNA (dsDNA), but the source of DNA antigen is unknown. The TREX1 D18N mutation causes a monogenic, cutaneous form of lupus called familial chilblain lupus, and the TREX1 D18N enzyme exhibits dysfunctional dsDNA-degrading activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25848017
DOI: 10.1073/pnas.1423804112
PMCID: PMC4413332

Genes

TREX1

Variants

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Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.PMID 25848017Read ↗

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