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Article

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2002

Bertocci Barbara, De Smet Annie, Flatter Eric, Dahan Auriel, Bories Jean-Christophe, Landreau Catherine, Weill Jean-Claude, Reynaud Claude-Agnès

Abstract excerpt

Mutations arising in Ig V genes during an immune response are most likely introduced by one or several error-prone DNA polymerases. Many of the recently described nonreplicative DNA polymerases have an intrinsic fidelity compatible with such an activity, the strongest candidates being polymerase (pol) eta, pol iota, pol zeta, and pol mu. We report in this work that mice inactivated for either of the two...

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Identifiers

PMID: 11937519
DOI: 10.4049/jimmunol.168.8.3702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.PMID 11937519Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.Semantic proximity Read ↗

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.Semantic proximity Read ↗

Transcription, beta-like DNA polymerases and hypermutation.Semantic proximity Read ↗

Emerging links between hypermutation of antibody genes and DNA polymerases.Semantic proximity Read ↗

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.Semantic proximity Read ↗

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Semantic proximity Read ↗

DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation.Semantic proximity Read ↗

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.Semantic proximity Read ↗

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Semantic proximity Read ↗

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.Semantic proximity Read ↗

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.Semantic proximity Read ↗

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