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Article

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.

PloS one - 1 Jan 2022

Rahim Tania, Levinson Madison A, Carufe Kelly E W, Burak Matthew, Meas Rithy, Maher Stephen, Bothwell Alfred L M, Gades Naomi, Sweasy Joann B

Abstract excerpt

Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35486639
DOI: 10.1371/journal.pone.0267913
PMCID: PMC9053796

Genes

POLB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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