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Article

Mutation of POLB causes lupus in mice.

Cell reports - 16 Jan 2014

Senejani Alireza G, Liu Yanfeng, Kidane Dawit, Maher Stephen E, Zeiss Caroline J, Park Hong-Jae, Kashgarian Michael, McNiff Jennifer M, Zelterman Daniel, Bothwell Alfred L M, Sweasy Joann B

Abstract excerpt

A replication study of a previous genome-wide association study (GWAS) suggested that a SNP linked to the POLB gene is associated with systemic lupus erythematosus (SLE). This SNP is correlated with decreased expression of Pol β, a key enzyme in the base excision repair (BER) pathway. To determine whether decreased Pol β activity results in SLE, we constructed a mouse model of POLB that encodes an enzyme with...

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Share to DNA Polymerase beta
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred C57BL

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to V(D)J Recombination

Source

Open in PubMed Open full text

Identifiers

PMID: 24388753
DOI: 10.1016/j.celrep.2013.12.017
PMCID: PMC3916967

Genes

POLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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