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Article

Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2021

Murakami Kosuke, Kanto Akiko, Sakai Kazuko, Miyagawa Chiho, Takaya Hisamitsu, Nakai Hidekatsu, Kotani Yasushi, Nishio Kazuto, Matsumura Noriomi

Abstract excerpt

Recent studies have reported cancer-associated mutations in normal endometrium. Mutations in eutopic endometrium may lead to endometriosis and endometriosis-associated ovarian cancer. We investigated PIK3CA mutations (PIK3CAm) for three hotspots (E542K, E545K, H1047R) in eutopic endometrium in patients with ovarian cancer and endometriosis from formalin-fixed paraffin-embedded specimens by laser-capture...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34172890
DOI: 10.1038/s41379-021-00861-3
PMCID: PMC8514336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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