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Article

PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma.

Virchows Archiv : an international journal of pathology - 1 Jan 2012

Yamamoto Sohei, Tsuda Hitoshi, Takano Masashi, Tamai Seiichi, Matsubara Osamu

Abstract excerpt

Somatic mutations of PIK3CA and ARID1A are the most common genetic alterations observed in ovarian clear cell adenocarcinomas (CCA). In a previous report, we showed that PIK3CA gene mutations and loss of ARID1A expression occur early during the development of CCA. In the present study, using direct genomic DNA sequencing for exons 9 and 20 of PIK3CA and immunohistochemistry for ARID1A protein expression, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22120431
DOI: 10.1007/s00428-011-1169-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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