Article
PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.
Human pathology - 1 Nov 2011
Konopka Bożena, Janiec-Jankowska Aneta, Kwiatkowska Ewa, Najmoła Urszula, Bidziński Mariusz, Olszewski Włodzimierz, Goluda Cyprian
Abstract excerpt
Alterations of the PIK3CA gene occur in endometrial carcinomas, but their role in the carcinogenesis of those malignancies is still poorly understood. In this study, PIK3CA mutations and amplification in 196 endometrioid endometrial carcinomas and 20 endometrial hyperplasias were assessed by single-strand conformation polymorphism (PCR-SSCP), sequencing, and quantitative polymerase chain reaction. Results were...
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