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Article

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

The Journal of pathology - 1 Jun 2015

Anglesio Michael S, Bashashati Ali, Wang Yi Kan, Senz Janine, Ha Gavin, Yang Winnie, Aniba Mohamed R, Prentice Leah M, Farahani Hossein, Li Chang Hector, Karnezis Anthony N, Marra Marco A, Yong Paul J, Hirst Martin, Gilks Blake, Shah Sohrab P, Huntsman David G

Abstract excerpt

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted sequencing in synchronous endometriosis, we have investigated how this carcinoma may evolve from endometriosis. In every case we observed multiple tumour-associated somatic...

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Share to Adenocarcinoma, Clear Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25692284
DOI: 10.1002/path.4516
PMCID: PMC6680210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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