Cancer-Associated Mutations in Endometriosis without Cancer.

doi:10.1056/NEJMoa1614814

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Article

Cancer-Associated Mutations in Endometriosis without Cancer.

The New England journal of medicine - 11 May 2017

Anglesio Michael S, Papadopoulos Nickolas, Ayhan Ayse, Nazeran Tayyebeh M, Noë Michaël, Horlings Hugo M, Lum Amy, Jones Siân, Senz Janine, Seckin Tamer, Ho Julie, Wu Ren-Chin, Lac Vivian, Ogawa Hiroshi, Tessier-Cloutier Basile, Alhassan Rami, Wang Amy, Wang Yuxuan, Cohen Joshua D, Wong Fontayne, Hasanovic Adnan, Orr Natasha, Zhang Ming, Popoli Maria, McMahon Wyatt, Wood Laura D, Mattox Austin, Allaire Catherine, Segars James, Williams Christina, Tomasetti Cristian, Boyd Niki, Kinzler Kenneth W, Gilks C Blake, Diaz Luis, Wang Tian-Li, Vogelstein Bert, Yong Paul J, Huntsman David G, Shih Ie-Ming

Abstract excerpt

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27...

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Identifiers

PMID: 28489996
DOI: 10.1056/NEJMoa1614814
PMCID: PMC5555376

Genes

KRAS

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