Article
Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and clear cell carcinomas.
American journal of clinical pathology - 1 Sept 2015
Matsumoto Toshihide, Yamazaki Masaaki, Takahashi Hiroyuki, Kajita Sabine, Suzuki Erina, Tsuruta Tomoko, Saegusa Makoto
Abstract excerpt
OBJECTIVES: We focused on the differences in molecular mechanisms in the early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and ovarian clear cell carcinoma (OCCCa). METHODS: Alterations in the β-catenin and PIK3CA genes, as well as expression of their associated markers, were investigated. RESULTS: Mutations in exon 3 of the β-catenin gene were identified in 21 (60%) of 35 OEMCas....
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