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Article

PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma.

The Journal of pathology - 1 Oct 2011

Yamamoto Sohei, Tsuda Hitoshi, Takano Masashi, Iwaya Keichi, Tamai Seiichi, Matsubara Osamu

Abstract excerpt

Clear cell adenocarcinoma (CCA), a highly lethal histological subtype of ovarian carcinoma, is a type of human cancer with a high frequency of activating mutations in the PIK3CA gene. In this study, we aimed to determine how these mutations contribute to tumour development of CCAs. Exons 9 and 20 of the PIK3CA gene were analysed by direct genomic DNA sequencing of 23 CCAs with synchronous putative precursor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21735444
DOI: 10.1002/path.2940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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