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Article

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2006

Hayes Monica Prasad, Wang Hong, Espinal-Witter Rosanny, Douglas Wayne, Solomon Garron J, Baker Suzanne J, Ellenson Lora Hedrick

Abstract excerpt

PURPOSE: The tumor suppressor PTEN gene and the PIK3CA oncogene are frequently mutated in uterine endometrioid carcinoma (UEC). PTEN mutations are also common in complex atypical hyperplasia (CAH), the precursor lesion of UEC. The status of PIK3CA has not yet been explored in CAH. In this study, we evaluated both CAH and UEC for PTEN and PIK3CA mutations. EXPERIMENTAL DESIGN: Neoplastic tissue was microdissected,...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17062663
DOI: 10.1158/1078-0432.CCR-06-1375

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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