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Article

A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2011

Rudd Meghan L, Price Jessica C, Fogoros Sarah, Godwin Andrew K, Sgroi Dennis C, Merino Maria J, Bell Daphne W

Abstract excerpt

PURPOSE: The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid endometrial cancer (NEEC). EXPERIMENTAL DESIGN: We resequenced all coding exons of PIK3CA and PTEN, and exons 1 and 2 of KRAS, from 108 primary endometrial tumors. Somatic mutations were confirmed by sequencing matched normal DNAs. The...

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Identifiers

PMID: 21266528
DOI: 10.1158/1078-0432.CCR-10-0540
PMCID: PMC3060282

Genes

KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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