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Article

Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021

Miller Simon, Srivastava Ashutosh, Nagai Yoshiko, Aikawa Yoshiki, Tama Florence, Hirota Tsuyoshi

Abstract excerpt

The circadian clock is a biological timekeeper that operates through transcription-translation feedback loops in mammals. Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are highly conserved core clock components having redundant and distinct functions. We recently identified the CRY1- and CRY2-selective compounds KL101 and TH301, respectively, which provide useful tools for the exploration of isoform-selective...

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Identifiers

PMID: 34172584
DOI: 10.1073/pnas.2026191118
PMCID: PMC8255803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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