Dynamic regulation of the serine loop by distant mutations reveals allostery in cryptochrome1.

Abstract excerpt

Cryptochromes (CRYs) are essential components of the molecular clock that generates circadian rhythm. They inhibit BMAL1/CLOCK-driven transcription at the molecular level. There are two CRYs that have differential functions in the circadian clock in mammals. It is not precisely known how they achieve such differential functions. In this study, we performed molecular dynamic simulations on eight CRY mutants that...

Topics

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• Allosteric Regulation
• Cryptochromes
• BMAL1 gene
• CRY2 gene
• Molecular Dynamics Simulation